Inhibitory activity of plant extracts on nitric oxide synthesis in LPS-activated macrophages.
Identifieur interne : 004428 ( Main/Exploration ); précédent : 004427; suivant : 004429Inhibitory activity of plant extracts on nitric oxide synthesis in LPS-activated macrophages.
Auteurs : Jae-Ha Ryu [Corée du Sud] ; Hanna Ahn ; Ji Yeon Kim ; Young-Kyoon KimSource :
- Phytotherapy research : PTR [ 0951-418X ] ; 2003.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Artemisia (MeSH), Equisetum (MeSH), Extraits de plantes (pharmacologie), Lignée cellulaire (MeSH), Lipopolysaccharides (pharmacologie), Macrophages (effets des médicaments et des substances chimiques), Macrophages (métabolisme), Monoxyde d'azote (biosynthèse), Morus (MeSH), Populus (MeSH), Relation dose-effet des médicaments (MeSH).
- MESH :
- biosynthèse : Monoxyde d'azote.
- effets des médicaments et des substances chimiques : Macrophages.
- métabolisme : Macrophages.
- pharmacologie : Extraits de plantes, Lipopolysaccharides.
- Animaux, Artemisia, Equisetum, Lignée cellulaire, Morus, Populus, Relation dose-effet des médicaments.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Nitric Oxide.
- chemical , pharmacology : Lipopolysaccharides, Plant Extracts.
- drug effects : Macrophages.
- metabolism : Macrophages.
- Animals, Artemisia, Cell Line, Dose-Response Relationship, Drug, Equisetum, Morus, Populus.
Abstract
Nitric oxide (NO) produced in large amounts by inducible nitric oxide synthase (iNOS) is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. Inhibitors of iNOS, thus, may be useful candidates for the treatment of inflammatory diseases accompanied by overproduction of NO. We prepared alcoholic extracts of woody plants and screened the inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages after the treatment of these extracts. Among 83 kinds of plant extracts, 23 kinds of extracts showed potent inhibitory activity of NO production above 60% at the concentration of 80 micro g/ml. Some of potent extracts showed dose dependent inhibition of NO production of LPS-activated macrophages at the concentration of 80, 40, 20 micro g/ml. Especially, Artemisia iwayomogi, Machilus thunbergii, Populus davidiana and Populus maximowiczii showed the most potent inhibition (above 70%) at the concentration of 40 micro g/ml. Inhibitory activity of NO production was concentrated to nonpolar solvent fractions (ethyl ether and/or ethyl acetate soluble fractions) of Artemisia iwayomogi, Machilus thunbergii and Morus bombycis. These plants are promising candidates for the study of the activity-guided purification of active compounds and would be useful for the treatment of inflammatory diseases and endotoxemia accompanying overproduction of NO.
DOI: 10.1002/ptr.1180
PubMed: 12748984
Affiliations:
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Kyoon" sort="Kim, Young Kyoon" uniqKey="Kim Y" first="Young-Kyoon" last="Kim">Young-Kyoon Kim</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:12748984</idno><idno type="pmid">12748984</idno><idno type="doi">10.1002/ptr.1180</idno><idno type="wicri:Area/Main/Corpus">004463</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">004463</idno><idno type="wicri:Area/Main/Curation">004463</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">004463</idno><idno type="wicri:Area/Main/Exploration">004463</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inhibitory activity of plant extracts on nitric oxide synthesis in LPS-activated macrophages.</title><author><name sortKey="Ryu, Jae Ha" sort="Ryu, Jae Ha" uniqKey="Ryu J" first="Jae-Ha" last="Ryu">Jae-Ha Ryu</name><affiliation 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type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Artemisia (MeSH)</term><term>Cell Line (MeSH)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Equisetum (MeSH)</term><term>Lipopolysaccharides (pharmacology)</term><term>Macrophages (drug effects)</term><term>Macrophages (metabolism)</term><term>Morus (MeSH)</term><term>Nitric Oxide (biosynthesis)</term><term>Plant Extracts (pharmacology)</term><term>Populus (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Artemisia (MeSH)</term><term>Equisetum (MeSH)</term><term>Extraits de plantes (pharmacologie)</term><term>Lignée cellulaire (MeSH)</term><term>Lipopolysaccharides (pharmacologie)</term><term>Macrophages (effets des médicaments et des substances chimiques)</term><term>Macrophages (métabolisme)</term><term>Monoxyde d'azote (biosynthèse)</term><term>Morus (MeSH)</term><term>Populus (MeSH)</term><term>Relation dose-effet des médicaments (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Nitric Oxide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Lipopolysaccharides</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Monoxyde d'azote</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Extraits de plantes</term><term>Lipopolysaccharides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Artemisia</term><term>Cell Line</term><term>Dose-Response Relationship, Drug</term><term>Equisetum</term><term>Morus</term><term>Populus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Artemisia</term><term>Equisetum</term><term>Lignée cellulaire</term><term>Morus</term><term>Populus</term><term>Relation dose-effet des médicaments</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nitric oxide (NO) produced in large amounts by inducible nitric oxide synthase (iNOS) is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. Inhibitors of iNOS, thus, may be useful candidates for the treatment of inflammatory diseases accompanied by overproduction of NO. We prepared alcoholic extracts of woody plants and screened the inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages after the treatment of these extracts. Among 83 kinds of plant extracts, 23 kinds of extracts showed potent inhibitory activity of NO production above 60% at the concentration of 80 micro g/ml. Some of potent extracts showed dose dependent inhibition of NO production of LPS-activated macrophages at the concentration of 80, 40, 20 micro g/ml. Especially, Artemisia iwayomogi, Machilus thunbergii, Populus davidiana and Populus maximowiczii showed the most potent inhibition (above 70%) at the concentration of 40 micro g/ml. Inhibitory activity of NO production was concentrated to nonpolar solvent fractions (ethyl ether and/or ethyl acetate soluble fractions) of Artemisia iwayomogi, Machilus thunbergii and Morus bombycis. These plants are promising candidates for the study of the activity-guided purification of active compounds and would be useful for the treatment of inflammatory diseases and endotoxemia accompanying overproduction of NO.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12748984</PMID><DateCompleted><Year>2003</Year><Month>07</Month><Day>31</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0951-418X</ISSN><JournalIssue CitedMedium="Print"><Volume>17</Volume><Issue>5</Issue><PubDate><Year>2003</Year><Month>May</Month></PubDate></JournalIssue><Title>Phytotherapy research : PTR</Title><ISOAbbreviation>Phytother Res</ISOAbbreviation></Journal><ArticleTitle>Inhibitory activity of plant extracts on nitric oxide synthesis in LPS-activated macrophages.</ArticleTitle><Pagination><MedlinePgn>485-9</MedlinePgn></Pagination><Abstract><AbstractText>Nitric oxide (NO) produced in large amounts by inducible nitric oxide synthase (iNOS) is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. Inhibitors of iNOS, thus, may be useful candidates for the treatment of inflammatory diseases accompanied by overproduction of NO. We prepared alcoholic extracts of woody plants and screened the inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages after the treatment of these extracts. Among 83 kinds of plant extracts, 23 kinds of extracts showed potent inhibitory activity of NO production above 60% at the concentration of 80 micro g/ml. Some of potent extracts showed dose dependent inhibition of NO production of LPS-activated macrophages at the concentration of 80, 40, 20 micro g/ml. Especially, Artemisia iwayomogi, Machilus thunbergii, Populus davidiana and Populus maximowiczii showed the most potent inhibition (above 70%) at the concentration of 40 micro g/ml. Inhibitory activity of NO production was concentrated to nonpolar solvent fractions (ethyl ether and/or ethyl acetate soluble fractions) of Artemisia iwayomogi, Machilus thunbergii and Morus bombycis. These plants are promising candidates for the study of the activity-guided purification of active compounds and would be useful for the treatment of inflammatory diseases and endotoxemia accompanying overproduction of NO.</AbstractText><CopyrightInformation>Copyright 2003 John Wiley & Sons, Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ryu</LastName><ForeName>Jae-Ha</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>College of Pharmacy, Sookmyung Women's University, Seoul, Korea. ryuha@sdic.sookmyung.ac.kr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahn</LastName><ForeName>Hanna</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Ji Yeon</ForeName><Initials>JY</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Young-Kyoon</ForeName><Initials>YK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Phytother Res</MedlineTA><NlmUniqueID>8904486</NlmUniqueID><ISSNLinking>0951-418X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008070">Lipopolysaccharides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>31C4KY9ESH</RegistryNumber><NameOfSubstance UI="D009569">Nitric Oxide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019306" MajorTopicYN="N">Artemisia</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020829" MajorTopicYN="N">Equisetum</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008070" MajorTopicYN="N">Lipopolysaccharides</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008264" MajorTopicYN="N">Macrophages</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D031625" MajorTopicYN="N">Morus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009569" MajorTopicYN="N">Nitric Oxide</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D032107" MajorTopicYN="N">Populus</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>5</Month><Day>16</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>8</Month><Day>2</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>5</Month><Day>16</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12748984</ArticleId><ArticleId IdType="doi">10.1002/ptr.1180</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Corée du Sud</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><noCountry><name sortKey="Ahn, Hanna" sort="Ahn, Hanna" uniqKey="Ahn H" first="Hanna" last="Ahn">Hanna Ahn</name><name sortKey="Kim, Ji Yeon" sort="Kim, Ji Yeon" uniqKey="Kim J" first="Ji Yeon" last="Kim">Ji Yeon Kim</name><name sortKey="Kim, Young Kyoon" sort="Kim, Young Kyoon" uniqKey="Kim Y" first="Young-Kyoon" last="Kim">Young-Kyoon Kim</name></noCountry><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Ryu, Jae Ha" sort="Ryu, Jae Ha" uniqKey="Ryu J" first="Jae-Ha" last="Ryu">Jae-Ha Ryu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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